期刊
BIOMATERIALS
卷 26, 期 18, 页码 3771-3782出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.10.002
关键词
polyhydroxybutyric acid; polymerisation; scaffold; degradation
Recent advances in the synthesis of poly(gamma-butyrolactone) have yielded homopolymers of up to 50,000Mw from the low-cost monomer gamma-butyrolactone. This monomer has for the better part of a century been thought impossible to polymerise. Poly(gamma-butyrolactone) displays properties that are ideal for tissue-engineering applications and the bacterially derived equivalent, poly(4-hydroxybutyrate) (P4HB), has been evaluated for such uses. The glass transition temperature (-48 to -51 degreesC), melting point (53-60degreesC), tensile strength (50 MPa), Young's modulus (70 MPa) and elongation at break (1000%) of P4HB make it a very useful biomaterial. Poly(gamma-butyrolactone) degrades to give gamma-hydroxybutyric acid which is a naturally occurring metabolite in the body and it has been shown to be bioresorbable. Investigation into the synthesis of poly(gamma-butyrolactone) has recently produced homo-oligomeric diols 400-1000Mw that are suitable for reacting with diisocyanates to form polyurethanes. Biodegradable polyurethanes made from diols of polyglycolide (PGA) and poly(epsilon-caprolactone) (PCL) have the disadvantage of high glass transition and slow degradation, respectively. Poly(gamma-butyrolactone) can be thought of as being the missing link in the biodegradable polyester family immediately between PGA and PCL and displaying intermediate properties. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据