Characterisation of Diclofenac, Ketoprofen or Chloramphenicol Succinate encapsulated in layered double hydroxides with the hydrotalcite-type structure

Three series of hybrid organic-inorganic layered double hydroxide samples containing Zn2+ and/or Mg2+ and Al3+ in the brucite-like layers (nominal M2+/Al molar ratio 2:1) and Diclofenac, Ketoprofen or Chloramphenicol Succinate as counter-anions, were synthesized by coprecipitation using drug/Al molar ratios of 2:1 to prepare the starting solutions. All samples have been characterised by element chemical analysis, powder X-ray diffraction, MIR spectroscopy, thermal analysis and morphology analysis (Scanning Electron Microscopy). The nanohybrids here prepared show a rather high crystallinity degree and the drug molecules are strongly interacting with the brucite-like layers. (C) 2011 Elsevier B.V. All rights reserved.