期刊
BRAIN RESEARCH REVIEWS
卷 48, 期 3, 页码 509-526出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2004.11.001
关键词
attention; basal ganglia; decision making; executive function; microstimulation; neostriatum; neural circuit; neural system; prefrontal cortex; recording; reward; working memory
Tracing the neural circuitry of decision formation is a critical step in the understanding of higher cognitive function. To make a decision, the primate brain coordinates dynamic interactions between several cortical and subcortical areas that process sensory, cognitive, and reward information. In selecting the optimal behavioral response, decision mechanisms integrate the accumulating evidence with reward expectation and knowledge from prior experience, and deliberate about the choice that matches the expected outcome. Linkages between sensory input and behavioral output responsible for response selection are shown in the neural activity of structures from the prefrontal -basal gangliathalamo-cortical loop. The deliberation process can be best described in terms of sensitivity, selection bias, and activation threshold. Here, we show a systems neuroscience approach of the visual saccade decision circuit and the interaction between its components during decision formation. (c) 2004 Elsevier B.V. All rights reserved.
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