期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 347, 期 7-8, 页码 1035-1040出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200505027
关键词
Baeyer-Villiger oxidation; diketones; enzyme catalysis; lactones; monooxygenase
Cyclohexanone monooxygenase from Acinetobacter calcoaceticus was employed for the Baeyer-Villiger oxidation of racemic bicyclic diketones such as the Wieland-Miescher and the Hajos-Parrish diketones and of some of their derivatives. The corresponding lactones were produced in a highly regio- and enantioselective manner. The reactions were carried out using a crude enzyme preparation in aqueous buffer, at room temperature, and the recycling of the expensive coenzyme NADPH was conducted with a second ancillary enzymatic system. The enzymatic process was simple and easy to handle, thus providing a very practical tool to access enantiopure lactones.
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