Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models

Preliminary data examining interferon alfacon 1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon 1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect protection (CPE) assay, interferon alfacon I inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0.001 mu g/ml, a clinically achievable level. Furthermore, interferon alfacon 1 also demonstrated significant antiviral activity in yield reduction and plaque reduction assays. The in vitro antiviral activity of interferon alfacon 1 against SARS-CoV suggests continued evaluation of interferon alfacon 1 as a therapeutic treatment for patients infected with SARS-CoV. Published by Elsevier B.V.