期刊
NATURE IMMUNOLOGY
卷 6, 期 6, 页码 608-617出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1199
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- NCI NIH HHS [CA72531] Funding Source: Medline
T cell receptor engagement activates p21-activated kinase 1 (PAK1) through a LAT - SLP- 76 - Nck - Vav- Rac - dependent pathway. A second independent pathway involving a GIT-PIX- PAK1 trimolecular complex is also activated by T cell receptor ligation. Here we show a Vav- independent pathway exists that leads to PAK1 activation. In addition, PAK1, PIX and GIT1 were recruited to the T cell - antigen-presenting cell contact site independently of SLP- 76 and Vav1. PAK1 recruitment to the T cell - antigen-presenting cell interface required interaction with PIX, which also led to optimal PLC-gamma 1 activation and T cell receptor - dependent transcriptional responses. These data indicate that a pathway involving the GIT-PIX- PAK1 complex has a crucial function in PAK1 activation by recruiting PAK1 to the immunological synapse.
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