期刊
FITOTERAPIA
卷 76, 期 3-4, 页码 281-287出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2005.03.018
关键词
Comarum palustre; comaruman; antiinflammatory; leukocyte adhesion
A pectic polysaccharide named comaruman (CP) was extracted from the aerial part of Comarum palustre with 0.7% aqueous ammonium oxalate and subsequent precipitation with ethanol. Oral administration of comaruman (5-100 mg/kg) was found to reduce a paw edema observed 24 h after injection of 2% formalin in mice. A fraction of comaruman (CP-H9) exhibited a similar anti inflammatory activity. Comaruman, CP deprived of lipid, CP purified by proteins and CP fractions obtained with acidic hydrolysis inhibit spontaneous and phorbol-12-myristate-13-acetateactivated adhesion of peritoneal leukocytes in vitro. (c) 2005 Elsevier B.V. All rights reserved.
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