期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 93, 期 6, 页码 1214-1218出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.15-0033
关键词
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资金
- Sao Paulo Research Fecundativo (FAPESP)
- Centro de Estudos Emilio Ribas
The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.
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