Montmorillonite intercalated with vitamin B1 as drug carrier

Vitamin B-1 (thiamine hydrochloride, VB1) intercalated into montmorillonite (MMT), which was characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and thermo gravimetric analysis (TGA). The adsorption of VB1 on MMT increased with increase in reaction temperature. The adsorption isotherms were fitted by the Langmuir model. About 34 and 64% of the intercalated VB1 was released within 10 h, in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) respectively at 37 +/- 0.5 degrees C The release profile of VB1 followed the Higuchi kinetic model and the diffusion-controlled mechanism. During in vitro release experiments VB1 was released from MMT-VB1 steadily as a function of pH. (C) 2009 Elsevier B.V. All rights reserved.