期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 90, 期 6, 页码 3337-3341出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2004-1565
关键词
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Acromegaly Quality of Life Questionnaire (AcroQoL) is a new disease-generated quality of life (QOL) questionnaire comprising 22 questions covering physical and psychological aspects of acromegaly and subdivided into appearance and personal relations categories. We have performed a cross-sectional study of QOL in 80 patients [ 43 male ( mean age, 54.2 yr; range, 20 - 84); median GH, 0.93 ng/ml ( range, < 0.3 to 23.7); IGF-I, 333.1 ng/ml ( range, 47.7 - 899)] with acromegaly. In addition to AcroQoL, patients completed three generic QOL questionnaires: Psychological General Well-Being Schedule (PGWBS), EuroQol, and a signs and symptoms score (SSS). All three generic questionnaires confirmed impairment in QOL [ mean scores: PGWBS, 69.6; EuroQol, visual analog scale, 66.4 ( range, 20 - 100) and utility index, 0.7 ( range, - 0.07 to 0.92); and SSS, 12 ( range, 0 - 27)]. There was no correlation between biochemical control and any measure of QOL. AcroQoL (57.3%; range, 18.2 - 93.2) correlated with PGWBS ( r = 0.73; P < 0.0001); and in patients with active disease, AcroQoL-physical dimension correlated with SSS ( r = - 0.67; P < 0.0003). In all questionnaires, prior radiotherapy was associated with impaired QOL. In conclusion, these data underline the marked impact that acromegaly has on patients' QOL and provide the first evidence validating AcroQoL against well-authenticated measures of QOL. This indicates the potential of AcroQoL as a patient-friendly measure of disease activity.
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