期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 68, 期 -, 页码 S36-S42出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2005.03.013
关键词
HDL-C; metabolic syndrome; lipid lowering; statin; rosuvastatin
A low level of high-density lipoprotein cholesterol (HDL-C) is a key feature of the metabolic syndrome and type 2 diabetes. HDL particles exert an anti-atherogenic effect, and low HDL-C levels are associated with increased cardiovascular disease risk. The profile of lipoprotein sub-classes may also be abnormal in patients with the metabolic syndrome or type 2 diabetes, with an excess of atherogenic small low-density lipoprotein (LDL) particles. Statins are first-line lipid-modifying drugs that, in addition to varying in their effects on LDL-C, differ in their effects on HDL-C. Rosuvastatin has been shown to be at least as effective at increasing HDL-C compared with atorvastatin, pravastatin or sim vastatin. Selecting an agent that will increase HDL-C levels, as well as lowering LDLC levels, may be particularly beneficial in the treatment of patients with the metabolic syndrome and type 2 diabetes. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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