期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 33, 期 -, 页码 443-446出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0330443
关键词
alternative splicing; pre-mRNA splicing; RNA processing; RS domain; small nuclear ribonucleoprotein (RNP)
资金
- Medical Research Council [MC_U127584479] Funding Source: researchfish
- MRC [MC_U127584479] Funding Source: UKRI
- Medical Research Council [MC_U127584479] Funding Source: Medline
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SIR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. in the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.
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