期刊
COMPARATIVE AND FUNCTIONAL GENOMICS
卷 6, 期 4, 页码 251-255出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/cfg.479
关键词
genomics; pig genome; porcine; physical maps; sequencing consortium; whole-genome sequencing
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/R/00000684] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/R/00000684] Funding Source: Medline
The Swine Genome Sequencing Consortium (SGSC) was formed in September 2003 by academic, government and industry representatives to provide international coordination for sequencing the pig genome. The SGSC's mission is to advance biomedical research for animal production and health by the development of DNA-based tools and products resulting from the sequencing of the swine genome. During the past 2 years, the SGSC has met bi-annually to develop a strategic roadmap for creating the required scientific resources, to integrate existing physical maps, and to create a sequencing strategy that captured international participation and a broad funding base. During the past year, SGSC members have integrated their respective physical mapping data with the goal of creating a minimal tiling path (NITP) that will be used as the sequencing template. During the recent Plant and Animal Genome meeting (January 16, 2005 San Diego, CA), presentations demonstrated that a human-pig comparative map has been completed, BAC fingerprint contigs (FPC) for each of the autosomes and X chromosome have been constructed and that BAC end-sequencing has permitted, through BLAST analysis and RH-mapping, anchoring of the contigs. Thus, significant progress has been made towards the creation of a NITP. In addition, whole-genome (WG) shotgun libraries have been constructed and are currently being sequenced in various laboratories around the globe. Thus, a hybrid sequencing approach in which 3x coverage of BACs comprising the NITP and 3x of the WG-shotgun libraries will be used to develop a draft 6x coverage of the pig genome. Copyright © 2005 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据