期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 33, 期 -, 页码 499-501出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0330499
关键词
gene expression; ribonucleoprotein (RNP); herpes simplex virus; ICP27; nuclear export; pre-mRNA splicing
The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.
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