A pathophysiological paradigm for the therapy of psychiatric disease

Despite enormous progress in fundamental knowledge in neuroscience, no revolutionary therapies in psychiatry ( and neurology) have emerged in the past ten years. Most drugs alleviate symptoms, rather than restoring the 'set point' of brain function from a pathological position to a more normal one. We propose a hypothesis-driven, systems-level approach to drug discovery and development that is based on pathophysiology and which uses new animal models.