期刊
SEMINARS IN IMMUNOLOGY
卷 17, 期 3, 页码 183-191出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.02.007
关键词
homeostasis; T cells; cytokines
类别
资金
- NCI NIH HHS [CA38355] Funding Source: Medline
- NIAID NIH HHS [AI24187, AI45809, AI41079, AI46710] Funding Source: Medline
- NIA NIH HHS [AG20186, AG01743] Funding Source: Medline
The overall size and the composition of the mature T cell pool are regulated by homeostatic mechanisms. Recent work has revealed that homeostatic signals are received from contact with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from self-MHC/peptide ligands. In essence, homeostasis of naive T cells is regulated by IL-7 and self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-15. All of these signals also appear to be important to a varying degree for homeostasis of memory CD4 cells, but the details are less well understood than for other cell type. (c) 2005 Elsevier Ltd. All rights reserved.
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