期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 516, 期 2, 页码 180-181出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.04.040
关键词
IL-31; scratching; NC/Nga mice
To search for the pruritogen of atopic dermatitis, a characteristic symptom in atopic dermatitis patients, we examined interleukin-31 (IL-31) mRNA expression in NC/Nga mice as an animal model of atopic dermatitis. The expression of IL-31 mRNA in the skin of NC/Nga mice with scratching behavior was significantly higher than that in NC/Nga mice without scratching behavior. Our findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis. (c) 2005 Elsevier B.V All rights reserved.
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