期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 9, 期 3, 页码 266-276出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2005.04.003
关键词
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The amalgamation of two of combinatorial chemistry's most attractive concepts-natural product libraries and multicomponent reactions (MCRs)-should provide a powerful tactic for generating libraries of bioactive compounds. Yet, despite many recent advances in this area, only a few MCRs can deliver functionalized products whose structures closely resemble that of complex polycyclic natural products. A large proportion of recently developed MCRs are based on [4+2] or [3+2] cycloadditions, and isocyanide-based processes. Because of substrate limitations, however, they are not always ideally suitable for applications in diversity-oriented synthesis of natural product-like compounds. A promising area awaiting further development is the use of transition metalcatalyzed cascade reactions.
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