期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 7, 期 4, 页码 435-443出版社
WILEY
DOI: 10.1016/j.ejheart.2003.12.022
关键词
myocardial infarction; cellular cardiomyoplasty; wall thickening; myoblasts; magnetic resonance imaging; stein cells
资金
- NHLBI NIH HHS [R-01 HL-57988, HL-63703, HL-63346] Funding Source: Medline
Background: Contraction of transplanted myoblasts and their effects on function and remodeling after myocardial infarction remain controversial. Aim: We used magnetic resonance imaging (MRI) to study wall thickening and left ventricular (LV) function and geometry after myoblast transplantation. Methods and results: Three weeks after cryo-infarction rabbits were randomized to receive an injection of similar to 2 x 10(8) myoblasts (n=8) or medium (n=9) into the scar. Cine MRI and contrast enhanced (ce) MRI images were acquired before injection (baseline) and 4 weeks later (endpoint). Regional wall thickening was measured at the site of transmural hyperenhancement. In the control group, regional wall thickening decreased to - 15.3 +/- 8.6% at baseline, which further decreased to - 18.3 +/- 5.7% at endpoint. Further, end-diastolic volume increased from 3.96 +/- 0.27 to 5.00 +/- 0.46 ml and end-systolic volume from 2.23 +/- 0.19 to 2.96 +/- 0.30 ml (both P < 0.05 vs. baseline), which was accompanied by increased LV wall volumes (P < 0.05 vs. baseline). In contrast, myoblast transplantation increased regional wall thickening from - 11.9 +/- 15.9% at baseline to 26.9 +/- 17.0% (P < 0.05 vs. control), which resulted in significantly improved two-dimensional ejection fractions at the infarct level and prevented the increase in end-diastolic and end-systolic volumes and wall volume. Conclusion: Intracardiac myoblast transplantation after myocardial infarction improves regional wall thickening and prevents progressive left ventricular remodeling. (c) 2003 European Society of Cardiology. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据