期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 53, 期 6, 页码 607-610出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.607
关键词
Tripterygium wilfordii; xylem; sesquiterpene; immunosuppressive activity
Five new sesquiterpenes, 1 beta-furanoyl-2 beta,3 alpha,7 alpha,8 beta-pentaacetoxy-4 alpha,5 alpha-dihydroxy-dihydroagarofuran (1), 1 beta,2 beta,3 alpha,5 alpha,7 beta,8 beta,11-heptaacetoxy-dihydroagarofuran (2), 1 beta-furanoyl-2 beta,3 alpha 7 alpha,8 beta,11-pentaacetoxy-5 alpha hydroxy-dihydroagarofuran (3), l beta,7 beta,8 alpha-triacetoxy-2 beta-furanoyl-4 alpha-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1 beta-nicotinoyl-2 beta,5 alpha,7 beta-triacetoxy-4 alpha-hydroxy-11-isobutyryloxy-8 alpha-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.
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