期刊
SOUTHERN MEDICAL JOURNAL
卷 98, 期 6, 页码 590-595出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.SMJ.0000145300.28736.BB
关键词
ceftriaxone; outpatient parenteral antimicrobial therapy; skin infections; Staphylococcus aureus; vancomycin
Objectives: As increasing numbers of patients are being treated with outpatient parenteral antimicrobial therapy (OPAT), it becomes ever more important to ascertain the risks and benefits of such treatment for patients. Methods: We conducted a retrospective analysis of 1,5 15 patients with methicillin-sensitive Staphylococcus aureus infections who were treated with outpatient parenteral antimicrobial monotherapy. All patients were included in the adverse drug reaction analysis; 1,252 were evaluable for purposes of evaluating treatment efficacy. Results: The six antibiotics most frequently used in this study (ceftriaxone, cefazolin, vancomycin, oxacillin, nafcillin, and clindamycin) appeared to be equivalent in achieving the desired efficacy outcome. Conclusions: Vancomycin was associated with a significantly greater number of side effects than was ceftriaxone, cefazolin, or oxacillin, and nafcillin was associated with a significantly greater number of adverse events than ceftriaxone.
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