期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 11, 页码 3681-3689出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.03.030
关键词
Transport-P; prazosin; peptidergic neurones; V-ATPase-linked uptake
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential. (c) 2005 Elsevier Ltd. All rights reserved.
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