期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 12, 页码 4113-4123出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.03.036
关键词
antibacterial activity; linezolid; PH-027; 5-triazolylmethyl-oxazolidinone
A new series of N-linked 5-triazolylmethyl oxazolidinones with varying substitution at the piperazine nitrogen 4-position were synthesized and tested against a panel of Gram-positive and Gram-negative bacteria including clinical isolates. Most of the compounds showed excellent antibacterial activity against susceptible and resistant Gram-positive organisms. One of the compounds showed enhanced antibacterial activity against Moraxella catarrhalis. (c) 2005 Elsevier Ltd. All rights reserved.
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