Design and synthesis of new bis-pyridinium oxime reactivators for acetyleholinesterase inhibited by organophosphorous nerve agents

New bis-pyridinium oxime reactivators connected with a CH2CH2OCH2 linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4) M. (c) 2005 Elsevier Ltd. All rights reserved.