期刊
NEUROSCIENCE LETTERS
卷 380, 期 3, 页码 219-222出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.01.038
关键词
Alzheimer's disease; apolipoprotein CIII; apolipoprotein E; restriction fragment length polymorphism
In order to clarify the relationship of apolipoprotein CIII (APOC3) polymorphism and sporadic Alzheimer's disease (AD) in Chinese, 165 sporadic AD patients and 174 age-matched elderly individuals were genotyped for the APOC3 SstI and apolipoprotein E (APOE) HhaI polymorphisms. As the result, the APOC3 30176 allele was found to be associated with AD in APOE epsilon 4 allele noncarriers (x(2)=4.433, P=0.035), and the risk estimate of allele C versus G resulted in an OR of 1.56 (95% CI: 1.03-2.37), although in total no significant differences of allelic or genotypic frequencies between patients and controls were found. Assessment of interaction between APOE e4 and APOC3 30176 status presented an adjusted odds ratio of 0.62 (95% CI: 0.37-1.03) with a borderline significant P-value (P=0.066). Therefore, we conclude that the rare APOC3 G allele may offer some protection against the development of sporadic AD in APOE epsilon 4 noncarriers in Chinese. (c) 2005 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据