期刊
BEHAVIOURAL BRAIN RESEARCH
卷 161, 期 1, 页码 155-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2005.02.002
关键词
maternal behavior; animal models; depression; stress
In order to elucidate the relationship between maternal behavior and depression, the Flinders sensitive line (FSL) model of depression was studied and compared to Sprague-Dawley (SD) controls. Immobility in the swim test was measured, as an index for depressive-like behavior, and frequencies of maternal and non-maternal behaviors were recorded using short un-intrusive observations in the home cage. Lactating FSL rats displayed higher levels of immobility in the swim test compared to controls, indicating depressive-like behavior. In addition, compared to SD rats, FSL dams showed less frequent pup licking and non-nutritive contact with pups during the first and third weeks of lactation. In the third postpartum week, FSL dams showed less frequent nursing postures and more frequent self-directed behaviors. Thus, lactating FSL dams exhibit both depressed-like behavior and some abnormalities in maternal behavior. (c) 2005 Elsevier B.V. All rights reserved.
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