期刊
BEHAVIOURAL BRAIN RESEARCH
卷 161, 期 1, 页码 164-168出版社
ELSEVIER
DOI: 10.1016/j.bbr.2005.02.021
关键词
nicotine; self-administration; relapse; obesity; craving; conditioned reinforcement; drug seeking; cannabinoids; CB 1 receptors; sucrose; natural reward seeking
The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.
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