期刊
SCIENCE
卷 308, 期 5727, 页码 1463-1465出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1108661
关键词
-
资金
- Wellcome Trust Funding Source: Medline
The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelting nematodes, which are ubiquitous in their distribution worldwide. Here, we show that an increase in the rate of epithelial. cell turnover in the large intestine acts like an epithelia[ escalator to expel Trichuris and that the rate of epithelial cell movement is under immune control by the cytokine interieukin-13 and the chemokine CXCL10. This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.
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