期刊
JOURNAL OF CELL BIOLOGY
卷 169, 期 5, 页码 789-799出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200408005
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资金
- Wellcome Trust Funding Source: Medline
The lipid products of phosphoinositide 3-kinase (PI3K) are involved in many cellular responses such as proliferation, migration, and survival. Disregulation of PI3K-activated pathways is implicated in different diseases including cancer and diabetes. Among the three classes of PI3Ks, class I is the best characterized, whereas class II has received increasing attention only recently and the precise role of these isoforms is unclear. Similarly, the role of phosphatidylinositol-3-phosphate (PtdIns-3-P) as an intracellular second messenger is only just beginning to be appreciated. Here, we show that lysophosphatidic acid (LPA) stimulates the production of PtdIns-3-P through activation of a class II PI3K (PI3K-C2 beta). Both PtdIns-3-P and PI3K-C2 beta are involved in LPA-mediated cell migration. This study is the first identification of PtdIns-3-P and PI3K-C2 beta as downstream effectors in LPA signaling and demonstration of an intracellular role for a class II PI3K. Defining this novel PI3K-C2 beta- PtdIns-3-P signaling pathway may help clarify the process of cell migration and may shed new light on PI3K-mediated intracellular events.
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