Supercritical carbon dioxide as a reaction medium for enzymatic kinetic resolution of P-chiral hydroxymethanephosphinates

Kinetic resolution of racemic P-chiral hydroxymethanephosphinates via their lipase-promoted acetylation in supercritical carbon dioxide as the reaction medium was for the first time investigated Under various conditions. The reactivity and selectivity could be controlled by changing the pressure. (c) 2005 Elsevier Ltd. All rights reserved.