期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 127, 期 22, 页码 8146-8149出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja050471r
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资金
- NIGMS NIH HHS [GM58160] Funding Source: Medline
Bulky biaryl phosphine ligands facilitate Pd-catalyzed C-O coupling reactions of aryl halides with primary and secondary alcohols by promoting reductive elimination at the expense of beta-hydride elimination. The key to their success is the ability to match the size of the ligand to that of the combination of substrates. The efficient coupling of a number of unactivated aryl chlorides and bromides with cyclic and acyclic secondary alcohols was achieved. This included the coupling of allylic alcohols for the first time in a Pd-catalyzed coupling process.
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