期刊
FORENSIC SCIENCE INTERNATIONAL
卷 150, 期 2-3, 页码 161-164出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2004.11.025
关键词
proficiency; oral fluid; amfetamines; cannabinoids; cocaine; opiates; human gamma-globulin
Eighteen external quality assessment (proficiency testing) samples were prepared from client specimens collected with the Intercept (R) oral fluid collection device and by spiking drug-free oral fluid. Samples were circulated in pairs at quarterly intervals to 13 UK and USA based laboratories for analysis by a panel of OraSure micro-plate Intercept (R) enzyme immunoassay kits and hyphenated mass spectrophotometric techniques. During the survey, there was a single case of non-specificity in a false report for methadone. The major errors were of lack of sensitivity relative to the concentration thresholds specified for the immunoassays. The sensitivity for overall 'present'/'not found' reports calculated as true positives/(true positives + false negatives) were for the amfetamine specific assay 50%, methyl-amfetamines 93%, barbiturates 64%, cannabinoids 73%, cocaine and metabolites 100%, benzodiazepines 69%, methadone 95%, opiates 79% (opiates excluding oxycodone 93%), phencyclidine 93% and human gamma-globulin 97%. A small number of the sensitivity errors were attributable to errors in chromatographic confirmation techniques. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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