期刊
SCIENCE
卷 308, 期 5728, 页码 1587-1589出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1111445
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资金
- NIDDK NIH HHS [R21 DK063937] Funding Source: Medline
- NINDS NIH HHS [R01 NS22526, R01 NS11892] Funding Source: Medline
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.
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