期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1740, 期 3, 页码 319-325出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2004.10.010
关键词
diabetes; ginsenoside Re; intraperitoneal glucose tolerance test; insulin; microarray; ob/ob mouse
We evaluated the anti-diabetic effects of ginsenoside Re in adult male C57BL/6J ob/ob mice. Diabetic ob/ob mice with fasting blood glucose levels of approximately 230 mg/dl received daily intraperitoneal injections of 7, 20 and 60 mg/kg ginsenoside Re for 12 consecutive days. Dose-related effects of ginsenoside Re on fasting blood glucose levels were observed. After the 20 mg/kg treatment, fasting blood glucose levels were reduced to 188 +/- 9.2 and 180 +/- 10.8 mg/dl on Day 5 and Day 12, respectively (both P < 0.01 compared to vehicle group, 229 +/- 9.5 and 235 +/- 13.4 mg/dl, respectively). The EC70 of ginsenoside Re was calculated to be 10.3 mg/kg and was used for subsequent studies. Consistent with the reduction in blood glucose, there were significant decreases in both fed and fasting serum insulin levels in mice treated with ginsenoside Re. With 12 days of ginsenoside treatment, glucose tolerance of oblob mice increased significantly, and the area under the curve for glucose decreased by 17.8% (P < 0.05 compared to vehicle treatment). The hypoglycemic effect of the ginsenoside persisted even at 3 days of treatment cessation (blood glucose levels: 198 +/- 13.1 with ginsenoside treatment vs. 253 +/- 20.3 mg/dl with vehicle, P < 0.01). There were no significant changes in body weight or body temperature. Preliminary microarray analysis revealed differential expression of skeletal muscle genes associated with lipid metabolism and muscle function. The results suggest that ginsenoside Re may prove to be useful in treating type 2 diabetes. (c) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据