New cyclomaltoheptaose (β-cyclodextrin) derivative 2-O-(2-hydroxybutyl)cyclomaltoheptaose:: preparation and its application for the separation of enantiomers of drugs by capillary electrophoresis

A new soluble cyclornaltoheptaose (cyclodextrin) derivative, 2-O-(2-hydroxybutyl)cyclomaltoheptaose [2-O-(2-hydroxybutyl)-beta-cyclodextrin, 2-HB-beta-CD], was prepared and studied as an efficient chiral selector in the separation of racemic mixtures of drugs by capillary electrophoresis (CE). Results showed that 2-HB-beta-CD could provide higher separating capability than that of P-CD and the similarly substituted 2-HP-beta-CD. (c) 2005 Elsevier Ltd. All rights reserved.