期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2005, 期 12, 页码 2575-2579出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200400833
关键词
dihydroxykavain; mitsunobu reaction; natural products; sonochemistry; total synthesis
Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(+)-dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)-(-)-dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
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