期刊
JOURNAL OF CELL SCIENCE
卷 118, 期 12, 页码 2661-2670出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.02384
关键词
RhoB; Dia1; endocytosis; transport
类别
Rho GTPases are crucial regulators of the actin cytoskeleton and they play a role in the control of membrane trafficking. In contrast to the close family members RhoA and RhoC, RhoB localises to endosomes and delays epidermal growth factor receptor traffic. Here, we show that activated RhoB induces the peripheral distribution of endosomes, which align along subcortical actin stress fibres and are surrounded by an actin coat. The Diaphanous-related formin, Dial, is recruited to endosomes by activated RhoB. Dial is required for the formation of the actin coat around endosomes downstream of RhoB, connecting membrane trafficking with the regulation of actin dynamics.
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