Synthesis of substituted indole derivatives as a new class of antimalarial agents

A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.