期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 233, 期 1-2, 页码 183-198出版社
ELSEVIER
DOI: 10.1016/j.jns.2005.03.015
关键词
axonal degeneration; blood; cerebrospinal fluid; intermediate filaments; neurofilament; nfH; nfL; NfM; nomenclature; phosphorylation; surrogate marker; biomarker
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised. (c) 2005 Elsevier B.V All rights reserved.
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