The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists

Structure-activity relationship study of bipiperidine amide I has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13. (c) 2005 Elsevier Ltd. All rights reserved.