期刊
NEURON
卷 46, 期 6, 页码 849-855出版社
CELL PRESS
DOI: 10.1016/j.neuron.2005.05.029
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资金
- NICHD NIH HHS [HD23315] Funding Source: Medline
- NINDS NIH HHS [NS41073, NS21072] Funding Source: Medline
- DS NIH HHS [NINDS NS 37060] Funding Source: Medline
The three known inhibitors of axonal regeneration present in myelin-MAG, Nogo, and OMgp-all interact with the same receptor complex to effect inhibition via protein kinase C (PKC)-dependent activation of the small GTPase Rho. The transducing component of this receptor complex is the p75 neurotrophin receptor. Here we show that MAG binding to cerebellar neurons induces alpha- and then gamma-secretase proteolytic cleavage of p75, in a protein kinase C-dependent manner, and that this cleavage is necessary for both activation of Rho and inhibition of neurite outgrowth.
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