期刊
CELL
卷 121, 期 6, 页码 951-962出版社
CELL PRESS
DOI: 10.1016/j.cell.2005.03.031
关键词
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资金
- NCI NIH HHS [K01 CA098316, K01 CA098316-01] Funding Source: Medline
- NICHD NIH HHS [HD27211] Funding Source: Medline
- NIGMS NIH HHS [R01 GM079320, F32 GM019977] Funding Source: Medline
Cell invasion through basement membranes is crucial during morphogenesis and cancer metastasis. Here, we genetically dissect this process during anchor-cell invasion into the vulval epithelium in C. elegans. We have identified the fos transcription factor ortholog fos-1 as a critical regulator of basement-membrane removal. In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval cells, but these processes fail to remove the basement membranes separating the gonad from the vulval epithelium. fos-1 is expressed in the anchor cell and controls invasion cell autonomously. We have identified ZMP-1, a membrane-type matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibulin family extracellular matrix protein, as transcriptional targets of FOS-1 that promote invasion. These results reveal a key genetic network that controls basement-membrane removal during cell invasion.
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