期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 57, 期 9, 页码 1247-1265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2005.01.010
关键词
vaccine; biowarfare; plague; anthrax; botulinum toxin; smallpox; filovirus; liposome; polylactide; subunit; PLGA
Expanding identification of potentially protective subunit antigens and correlates of protection has provided a basis for the introduction of safer vaccines. Despite encouraging results in animal models, the significant potential of particulate delivery systems in vaccine design has not yet translated into effective vaccines available for use in humans. This review article will focus on the current status of the development of particulate vaccines, mainly liposomes and bio-degradable polymers, against potential agents for biowarfare: plague, anthrax, botulinum, and smallpox; and filoviruses: Marburg and Ebola. (c) 2005 Elsevier B.V. All rights reserved.
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