期刊
CARBOHYDRATE POLYMERS
卷 60, 期 4, 页码 483-487出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2005.03.014
关键词
calcium; calcium phosphate; inhibitor; phosphorylated chitooligosaccharides
Chitooligosaccharides (COSs) were successfully prepared using an ultrafiltration membrane bioreactor system, and named as COS-I (10-5 kDa), COS-II (5-3 kDa), COS-III (3-1 kDa), and COS-IV (below I kDa), respectively. In addition, their phosphorylated derivatives were prepared by a P(2)O(5) in methanesulfonic acid solution, and inhibitory activity on the formation of insoluble calcium phosphate of phosphorylated chitooligosaccharides. Phosphorylated COS-IV exhibited the highest inhibitory activity of calcium phosphate precipitation among tested chitooligosaccharides. Its inhibitory activity, especially at the concentration more than 4 mg/ml, was similar to that of CPP, which is widely used as a calcium fortifying agent increasing calcium absorbability. Therefore, phosphorylated chitooligosaccharides may be potential inhibitors of calcium phosphate precipitation. (c) 2005 Elsevier Ltd. All rights reserved.
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