期刊
CARBOHYDRATE POLYMERS
卷 60, 期 4, 页码 553-556出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2005.03.007
关键词
hetero-chitosans; sulfated derivatives; prolyl endopeptidase; competitive
Three kinds of partially deacetylated chitosan, 90% deacetylated chitosan, 75% deacetylated chitosan and 50% deacetylated chitosan, were prepared from crab chitin by N-deacetylation with 40% (w/w) sodium hydroxide solution for different durations. In order to improve biological activity and solubility, their sulfated derivatives were prepared, and prolyl endopeptidase (PEP) inhibitory activities were investigated. Fifty percent-deacetylated chitosan sulfate (50-CS) exhibited the highest inhibitory activity, and inhibition rate was a dose-dependant. In addition, Dixon plots suggested that 50-CS was act as competitive inhibitor, and the inhibition constant (K-i) was 2.6 mg/ml. (c) 2005 Elsevier Ltd. All rights reserved.
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