期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 11, 期 23, 页码 3628-3631出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v11.i23.3628
关键词
Downregulation; Gastric cancer
资金
- Provincial Natural Science Fund of Jiangsu [BK2002055]
- National Science Fund for Distinguished Young Scholars [30325017]
AIM: To discuss the expression of human leukocyte antigen (HLA) class I antigens in gastric cancer and correlate these with pathologic type and TNM stage. METHODS: The expression of HLA class I antigen was detected by immunohistochemistry in 185 specimens of gastric cancer, 20 gastric cancer specimens with lymphatic metastasis and 22 controls of normal gastric mucosa using four monoclonal antibodies. RESULTS: The expression of HLA class I antigen (B/C locus) was significantly downregulated in gastric cancer and in lymphatic metastasis than that in normal gastric mucosa (X-2 = 7.712, P<0.05). The expression of other HLA class I antigens was also downregulated, but the change was slight. There was no relationship between the downregulation of HLA class I antigen and that of beta 2m and LMP2. The expression of HLA class I (B/C locus) was statistically correlated with pathologic stage in gastric adenocarcinoma (X-2 = 4.164, P<0.05). CONCLUSION: The expression of HLA class I antigen (B/C locus) was obviously downregulated in gastric cancer and in lymphatic metastasis. This abnormal expression would provide the tumor cells with a way to avoid immunological recognition. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
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