期刊
CURRENT BIOLOGY
卷 15, 期 12, 页码 1099-1107出版社
CELL PRESS
DOI: 10.1016/j.cub.2005.05.053
关键词
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资金
- NEI NIH HHS [R01 EY006837-17, R37 EY006837, R37 EY006837-14, R01 EY006837, R37 EY006837-15, R01 EY006837-18, R01 EY006837-16A1, R01 EY014596-02, R01 EY014596-01, R01 EY014596, R01 EY014596-03, R37 EY006837-15S1] Funding Source: Medline
- NIDCD NIH HHS [R01 DC006904, R01 DC006904-01] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Background: The visual system is now known to be composed of image-forming and non-image-formin pathways. Photoreception for the image-forming pathway begins at the rods and cones, whereas that for the non-image-forming pathway also involves intrinsically photosensitive retinal ganglion cells (ipRGCs), which express the photopigment melanopsin. In the mouse retina, the rod and cone photoreceptors become light responsive from postnatal day 10 (P10); however, the development of photosensitivity of the ipRGCs remains largely unexplored. Results: Here, we provide direct physiological evidence that the ipRGCs are light responsive from birth (130) and that this photosensitivity requires melanopsin expression. Interestingly, the number of ipRGCs at PO is over five times that in the adult retina, reflecting an initial overproduction of melanopsin-expressing cells during development. Even at 130, the ipRGCs form functional connections with the suprachiasmatic nucleus, as assessed by light-induced Fos expression. Conclusions: The findings suggest that the non-image-forming pathway is functional long before the mainstream image-forming pathway during development.
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