期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 102, 期 1, 页码 169-171出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2004.10.041
关键词
acute coronary syndrome (ACS); nerve growth factor (NGF); brain-derived neurotrophic factor (BDNF)
To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Plasma concentrations of glucose, total cholesterol, triglycerides, LDL, HDL, creatin kinase (CK), NIB isoenzyme CK (CK-MB) were also measured with routine laboratory methods. We found reduced plasma levels of both NGF and BDNF in patients with ACS. These observations supports the hypothesis that one or both of these neurotrophins may be implicated in the pathogenesis of human coronary atherosclerosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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