Chiral Bronsted acid catalyzed enantioselective hydrophosphonylation of imines:: Asymmetric synthesis of α-amino phosphonates

A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Bronsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. alpha-Amino phosphonates were obtained with good to high enantioselectivities.