期刊
SCIENCE
卷 308, 期 5730, 页码 1906-1908出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1111781
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资金
- NIAID NIH HHS [AI51445, P0-1 AI52816] Funding Source: Medline
The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2175 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing, antibody responses by using HIV-1 vaccines.
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